Effect of Aqueous Extract of Melia azedarach on the some Biochemical Parameters in the Liver Extract of Infected Mice by Lieshmania donovani

Abstract

This study was designed to examine the effect of combined drugs (pentostam and allopurinol) 20mg / kg and  20,40,60,80 and 100  mg / kg of the aqueous fruit extract of M. azedarach on  infected mice for 10,15, and 20 days to determine their effect on some marker enzymes such as aspartate amino transferase  ( AST ) , alanine amino transferase  ( ALT ) , alkaline  phosphatase ( ALP ) , lactate dehydrogenase ( LDH ) and the biochemical parameters like glucose , cholesterol and total protein,

The present result showed a significant decrease  of  the two enzymes (AST and ALT) and significantly increased in (ALP and LDH) acivity  in comparison with the enzyme activities in the  liver  of  non– infected mice (con– ve). Where as the treated mice with 40 – 100mg / kg of aqueous fruit extract of the plant caused elevation in the activity of the (AST and ALT) and declining in (ALP and LDH ) activity when compared with infected non – treated mice           ( con+ ve) after 10 ,15 and 20days post infection .

The results also showed, non – significant differences in the glucose and cholesterol concentrations in infected mice in comparison with the non – infected mice. The treated mice with 20 mg/ kg pentostam/ allopurinol and 40 – 100 mg / kg of aqueous fruit extract of the plant caused  in significant  elevation of the glucose and cholesterol concentrations  in the liver of infected  mice in comparison with (con+ ve) after 10 , 15 and 20 days  post treatment , but the infection caused non – significant increased  in the total protein in liver of mice in comparison  with (con– ve) , the treated  mice  with 20mg / kg pentostam / allopurinol and 40–100 mg / kg from aqueous  fruit extract  M.azedarach caused decrease  of total protein  when compared  with (cont+ ve) for 10 , 15 and 20 days post treatment .