The role of Interleukin 6 , C Reactive Protein ,C3and C4 Complement in Immunopathogenesis of Myocardial Infarction

Abstract

Background:Coronary artery disease is the leading cause of premature death in the developed world and is estimated to become, by 2020, the major cause of death worldwide. Objective:To Evaluate the role of interleukin 6 and acute phase proteins in immunopathogenesis of myocardial infarction.

Patients and Methods: This study was conducted in Baquba Teaching Hospital in Diyala province .Ninety blood sample were collected from patients with myocardial infarction, 62 (68.9%)were males and 28 (31.1%) were females with age range (25-90) years, control group (35) patient, a males were 28 (77.14%) , and females were 8 (22.86%) with age range (25-70) years.

Results: The results showed levels of Interlukine-6 was higher in patients (47.44 ± 30.50) pg / ml than control (37.13 ± 12.08) pg / ml with no significant difference and the positivity of C-reactive protein in patient group was (81.3%) than control group was (0%) ,with highly significant different , the level of C3 and C4 in present study was lower in patient than control group.The C3 complement level was (112.88) pg / ml which is lower  than control group (121.48 ±) pg / ml ,while C4 level was (19.73) pg / ml also lower than control group (26.81) pg / ml and significant difference was noticed among C4 .  

Conclusion:We concluded that there is high level of IL-6 in patients with myocardial infarction and significantly high levels of C-Reactive Protein in patients of Myocardial infarction while showed there are low concentration levels of C3 and C4complement in patients with myocardial infarction.