Early Diagnosis of Myocardial Infarction by Ischemia-Modified Albumin and Antioxidant Markers

Abstract

Background: Myocardial infarction and oxidative stress drive the damage to myocardial tissue, culminating in cell necrosis. The study measured IMA, TAC, DPPH, total protein, and serum albumin in patients with MI.

Objectives: To analyze and diagnose the usefulness of IMA concentration in patients with potential MI signs within six hours.

Patients and Methods: During the period from September 2024 to February 2025, eighty individuals diagnosed with myocardial infarction (MI) who were admitted to Baquba Teaching Hospital in Iraq were enrolled in this study. In addition, twenty healthy individuals were included as a control group. IMA was measured using an ELISA kit, while serum TAC, DPPH, total protein, and albumin were measured spectrophotometrically. 

Results: The MI group showed a significantly elevated serum IMA concentration compared to healthy controls (p < 0.001). Patients with MI showed lower antioxidant activity and reduced levels of antioxidant molecules. There was no apparent association between serum IMA and DPPH, TAC, total protein, or serum albumin. However, positive correlations emerged between TAC and DPPH (0.678, p < 0.001), total protein and serum albumin (0.640, p < 0.001), and TAC and serum albumin (0.575, p < 0.001).

Conclusion: The aim of the study was to elucidate the crucial role of measuring IMA, TAC, DPPH, total protein, and serum albumin in patients with MI, alongside other oxidative stress indicators, to guide the development of targeted antioxidant treatments for early diagnosis.

Keywords: Myocardial infarction, IMA, Oxidative stress, Antioxidant, Ischemia.