Abnormal Uterine Bleeding: a Histopathological Study

Abstract

Background: Abnormal uterine bleeding (AUB) is considered as one of the most common and perplexing problems both to the patient and the gynecologist. Until the pathology underlying menorrhagia is accurately diagnosed, proper therapy is hardly possible.

Objective:  The objectives of the study were to determine the types and frequencies of pathologies in endometrial curettings of  abnormal  uterine  bleeding  &  compare  different  endometrial  pathologies  in  patient  to  age groups.

Material  and  Methods: a retrospective study in which H&E  sections  of  endometrial  curretings  of  152  patients  were  evaluated.  Diagnosis was made by correlating the morphological findings with the clinical history. 

Results: Out of 152 cases of AUB, 61.8% were due to organic causes, while 33.5% were dysfunctional in nature and seven (4.6%) specimens were insufficient for diagnosis. Of the organic causes of AUB, Table (3), low grade endometrial hyperplasia was the most frequent cause (41.5%) then pregnancy-related bleeding (31.9%). The most common histologic pattern in DUB was proliferative phase endometrium 45.1%, followed by secretory pattern 21.6%.

Conclusion:    Our  study  on  endometrial  curettings  in  abnormal  uterine  bleeding  revealed  clustering  of  cases  around Perimenopause.