Study of some biochemical parameters such as (Total serum bilirubin , Serum GOT , Serum GPT , Serum calcium and Serum ferritin) in thalassemia Patients

Abstract

Background: Thalassemia is a major health problem in developing and developed countries and suffers from many children of school age.

Objective:Study of some chemical parameters such as serum bilirubin and some liver enzymes such as GOT, GPT as well as calcium and ferritin in patients with thalassemia.

Patients and Methods: Analysis was performed on 109 patients with thalassemia in the thalassemia unit at Ibn al-Baladi Hospital for Women and Children in Baghdad Governorate. By spectrophotometer (Total serum bilirubin, GOT, GPT, serum calcium, hemoglobin) and vides device for serum fretin.

Results:Showed changes in thalassemia patients with an increase in bilirubin causing hyperbilirubinemia, an increase in GOT and GPT, decreased serum calcium levels in some thalassemia patients, and reduced hemoglobin density and reduced cell size, as well as increased serum ferrite in patients with thalassemia due to frequent blood transfusion.

Conclusion: This study shows an increase in blood vessels in all ages in both sexes due to the breakdown of red blood cells and the repeated blood transfusion, which causes the accumulation of iron in the body and the increase of enzymes and liver secretions (GOT, GPT) due to hepatic hypertrophy as well as increased bilirubin and calcium deficiency in serum thalassemia patients.