Comparative Study of Topical 1% Terbinafine Cream Versus 1% Clotrimazole Cream in The Treatment of Tineapedis

Abstract

Background:Tinea pedis (athletic foot) is the most common dermatophytic fungal infection of the body. It may last for a short or long time and may recur after treatment.

Objective: To assessed and compared the effectiveness and safety of 1% terbinafine cream and 1% clotrimazole cream for the treatment of tinea pedis.

Patients and Methods: Randomized control trial was done in the outpatient clinic of dermatology department in Rizgary Teaching Hospital in Erbil. From March, 2019 to January, 2020. Sixty patients with tinea pedis diag-nosed clinically were included in this study. Thirty patients applied 1% terbinafine cream topically twice daily for one week and thirty patients applied 1% clotrimazole cream topically twice daily for four weeks. Scraping for fungi was performed before and after therapy. Efficacy was assessed by clini-cal cure and mycological cure. Clinical and mycological cure measured at weeks one, four and six.

Results: Mycological cure rates were 86.7% for terbinafine and 80% for clotrimazole at 4 weeks, 86.7% for terbinafine and 90% for clotrimazole at 6 weeks. At 4 weeks, terbinafine had an 83.3 percent clinical treatment rate and clotrimazole had a 76.67 percent clinical treatment rate; at 6 weeks, terbinafine had an 83.3 percent clinical treatment rate and clotrimazole had an 83.3 percent clinical treatment rate.

Conclusion: The study showed that one week terbinafine two times a day is as effective as four weeks clotrimazole two times a day as well as in terms of mycological treatments and efficient therapies.