Sarab M Alazawi Wafaa F Rodhan Fatin F Alkazazz Baqer Kh Huthefa


Background: Histidine is an important amino acid with important properties that enable it to play a vital part in many activities in the human body, such as proton buffering, metal ion chelation, scavenging of reactive oxygen and nitrogen species, erythropoiesis and the histaminergic system. This review presents the impact of histidine level fluctuation on the body function, the physiological role and metabolic pathway of histidine in various parts of the human's body. Also, we investigated that histamine production by Histidine decarboxylase gene and there is relationship between histidine food intake and level of Histamine in blood, which resulting in the obesity, anemia and other nutrition issues. In addition, a neurotransmitter is included oin histamine that is widely distributed throughout the human brain; its deficiency could cause problems in the nervous system. This study revealed that deficiency of histidine contributed to mental problems like Parkinson's disease (PD), schizophrenia (SCZ), kidney and prion disease as well. As a result, histidine is  important to keep human body healthy, and it is also found that hisidine is used as a suitable drug for people who have schizophrenia. This review  revealed that the correlation between histamine and asthma is still not well understood. So, this review will open way for researchers to focuses on this aspect. 



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