Toxoplasmosis in Relation to Entameba Histolytica and Giardia Lamblia Infection

Abstract

This study was carried out in Baghdad , on 150 individuals (82 females, 68 males )  , were divided into four groups on the bases of parasitological and serological findings : group I : Control healthy Individuals : negative for toxoplasmosis and E . histolytica  and  G. lamblia    ( 20, 13.3% )group II : positive for toxoplasmosis alone (30 , 20%), group III: positive forE histolytica ,and  G. lamblia (63 , 42%), group IV: positive for toxoplasmosis , E . histolytica and  G . lamblia ( Mixed infection  37 , 24.7% ).

The results of  this study showed highly significant increase in serum levels of interleukin

-12 ( IL- 12 ) in all groups especially in group IV , followed by group II .The serum level

of  Interferon –gamma ( IFN- g ) showed also significant  increase(P <0.05)in group IV, followed by group III , but nonsignificant (P >0.05) in group II .

There was also significant increase in serum concentration of IgG , IgM,and IgE in group

IV , but nonsignificant level was recorded in  IgE of group II .

When comparing group II with the group IV , there was significant  difference in serum

levels of  IL-12 , IFN-g , IgG , IgM and IgE .

It was concluded that mixed infection with these parasites could  provide a strong  synergestic 

action  to induce both  cell mediated and humoral  immunity .