Determination of Interleukin-35 in Sera of Male Patients with Chronic Renal Failure on Hemodialysis

Abstract

Background:- Renal failure may lead to increased inflammatory responses through a number of mechanisms which include decreased clearance of proinflammatory cytokines, decreased levels of antioxidant , that lead to increase of oxidative stress , nephrons are destroyed and kidney function is reduced .

Objective:- The aims of this study were to determination the differences in the levels of interleukin-35 (IL-35) in patients with chronic renal failure (CRF) on hemodialysis and compare with control group.

Method:- Sixty male individuals (age 40-60) were enrolled in this study which were divided into two groups as follows: Group (C) consisted of 30 healthy individuals as a control subject, (30) patients with (CRF) which were collected of their serum pre and post hemodialysis and control. IL-35, hs-CRP, TAC, MDA, MDA/TAC, urea, creatinine, uric acid, albumin levels were evaluated.

Results:- The results in this study revealed that mean of serum IL-35 levels were significantly increased differences in patients with (CRF) pre and post hemodialysis compared with control group and a significant positive correlation between IL-35 and (MDA, MDA/TAC) in patients with pre and post dialysis patients with CRF.

Conclusion:- Our findings suggest that a high IL-35 level most possibly reflect that the patients with (CRF) are associated and the positive correlation with oxidant-antioxidant status. Therefore, we suggest that possible antioxidant strategies that can be used therapeutically for better management of (CRF).