Lymphangiogenesis Using D2-40 in Oral Squamous Cell and Mucoepidermoid Carcinoma and its Correlation with Clinicopathological parameters

Abstract

Background: Oral squamous cell carcinoma (OSCC) and Mucoepidermoid carcinoma (MEC) are the most common malignant tumor of the oral cavity and salivary gland respectively, the extent of lymph node (LN) metastasis by lymphangiogenesis is a major determinant for the staging and the prognosis of these malignancies and often guides therapeutic decisions.

Objective: To correlate the lymphangiogenesis of OSCC and MEC with their clinicopathological parameters.

Material and Methods: Fifteen oral squamous cell carcinoma and eighteen mucoepidermoid carcinoma tissue samples collected during the period from 2008 till 2014. Age, gender, site of tumors and stage were reviewed. Lymphangiogenesis obtained by Immunohistochemical findings using D2-40 immunomarker. 

Results: All cases of OSCC and MEC exhibited positive immunostaining for lymphangiogenic marker. There is a correlation between OSCC and MEC regarding the age group and site of tumors (P=0.001), while gender, lymphatic vessel density (LVD) and TNM stage have no correlation with OSCC and MEC. Lymphatic vessel density and showed no relation with stage of OSCC and MEC.

Conclusion: No statistical correlation was found between LVD which expressed by mean of lymphangiogenesis using D2-40 immunomarker and OSCC MEC stage.