Bioeffects of 1.5T Static Magnetic Field on the DNA Strand of Human Leukocytes in Vitroduring MRI Scan

Abstract

Background: The non ionization of magnetic resonance fields effect sreported   with radical pair recombination. Which   is one of the familiar methods by which static magnetic felid interact with biological systems. Exposure to static magnetic fields can effect on the paramagnetic free radicals by increasing  the concentration, the activity and life time of paramagnetic free radicals, which might lead to genetic mutation, oxidative stress, and in some times with apoptosis.

Objective: To estimate the genotoxicity on DNA molecule during expose to static magnetic field 1.5T of magnetic resonance imaging.

Patients and Methods: The five blood   samples were irradiated  to 1.5T static magnetic field at different periods (10,20,30,40,and 50 minutes correspondingly). All exposures were performed at room temperature. Cellular  DNA damage had been  analyzed by the alkaline comet assay.                                                                    

Results: The results approved a significant increasing  in the rate of recurrence of single-strand DNA breaks next to the  exposure of  a 1.5T of magnetic resonance imaging at 50 min. According to these  results the exposure with 3T magnetic resonance imaging encourage genotoxic effects in human lymphocytes could be suggested.

Conclusion: To conclude, in the present study, employing alkaline comet assay, it has been demonstrated thatmagnetic resonance imaging- induced  DNA damages is significant in  leukocytes at 50 minute after exprosure to 1.5T magnetic resonance imaging.