Assessment of Neopterin and Interleukin-1 Beta Serum Levels in Burn Patients

Abstract

Background: The burn is an injury consisting of the destruction of the skin and the underlying tissues. The neopterin(Neo) is produced by activated macrophages, in response to interferon-gamma derived from activated T cell. Interleukin1 beta (IL-1β) is an important mediator of the inflammatory response.

Objective: Estimation of Neo and IL-1β in burned patients to determine the changes in these parameters in relation to percentage of total burn body surface area (TBSA%) and the duration of hospital stay.

Patients and Methods: Fifty burned patients who were admitted to West Erbil Emergency Hospital in Erbil governorate were included. Out of 50 burnt patients 20 patients were secondly sampled to follow-up serum levels for Neo and IL- β. The burn patients in this  study was divided into four groups according to the TBSA%.

Results: Comparing mean concentration of serum  Neo and IL-1β in burn patients and healthy control revealed increased levels of Neo and IL-1β in burnt patients with increased TBSA% , indeed IL-1β serum level also increased in non-survivor  burn patients compared with survivor patients and HC. Indeed levels of Neo level increased significantly in (10) day post burn.

Conclusion: Levels of Neo and IL-1β increased in burnt patients with increased TBSA%, non-survivor  compared with survivor patients and HC. Indeed levels of Neo level increased in (10) day post burn.