Evaluation of vitamin-D3 Concentration in Patients with Thalassemia in Baghdad City

Abstract

Background:Thalassemia is inherited blood disorders characterized by abnormal  hemoglobin production.

Objective:To evaluate decreasing in vitamin-D3 concentration in patients with thalassemia among healthy men in Baghdad city.

Patients and Methods: In this study containing 99 thalassemia patients from Baghdad city (68 female and 31 male patients) and (31 healthy males and 10 healthy women) as a control group collected from Al-Kadhymia hospital. Their age ranged (15-40) years old which are compatible to age of study group. Serum samples taken from the patients to determined vitamin-D concentration by using Enzyme Linked Immuno Sorbent Assay (ELISA) technique, during the period 1st April 2016 to 28th January 2017.

Results:The study revealed highly significant (P<0.01) low of vitamin-D3 concentration in patients with thalassemia (89.9% decrease vit-D3 compared with 10.1% control group vit-D3 concentration).

Conclusion:The decreasing in vitamin-D3 concentration associated with thalassemia patients was due to less exposure to sun light that affected the vitamin metabolism in their bodies.