Diyala Journal of Medicine 2021-10-23T12:49:03+00:00 Ass. Prof. Dr. Anfal Shakir Motib Open Journal Systems <p style="text-align: justify;">Diyala Journal of Medicine (DJM) was established according to agreement of Ministry of Higher Education and Scientific Research-foundation of as per authorization letter Number 12c/2433 in 19th August 2010. Fellow up, Started to receiving different manuscripts in all fields of medicine such as clinical, basic, dentist, pharmacology and scientific original articles. Diyala Journal of Medicine usually Deal with articles closely related with clinical problem more common in Iraq and Middle East. Also considered is a periodic peer-reviewed journal published biannually by the College of Medicine in Diyala University. However, review articles of high standards will be considered Writing in English languages with Arabic abstract.</p> <p><span style="font-size: 20px; font-family: Times New Roman;"><span style="font-size: 20px; color: #17365d;">&nbsp;</span></span></p> Evaluation of Some Serum Antioxidants in Mandibular Bone Defect Healing in Rabbits Orally Supplemented with Pomegranate Peel Extract 2021-10-23T12:38:54+00:00 Sarchil Ezadeen Mohyadeen Rezan Majeed Omer Bakhtiar Muhialdin Ahmed <p><strong>Background: </strong>Pomegranate (PG) fruit (punicagranatum L, Punicaceae contains many bioactive substances that play important role in the treatment of a variety of medical problems. Among PG parts, it was observed that the peel had the most potent antioxidant activity.</p> <p><strong>Objective:</strong> To evaluate some serum antioxidants levels in mandibular bone injury healing in rabbits orally supplemented with pomegranate peel extract (PPE).</p> <p><strong>Patients and Methods:</strong> Forty-five male rabbits (1-1.2 kg) were used and they were divided into 3 groups; the baseline group consisted of 5 rabbits without creating mandibular bone defects. 20 rabbits were used as a study group with creating mandibular bone defects and they received orally 1ml/day of PPE. Another 20 rabbits were used as a control group with creating mandibular bone defects without receiving PPE. For each rabbit of both study and control groups, a circular defect of 3 mm in diameter was made in the mid labial area of the alveolar bone of the lower right central incisor. Blood samples were taken from the baseline group and both the study and control groups at time intervals; 3hrs, 1, 3, and 7days after bone defect creation, for estimation of serum albumin (Alb), bilirubin (Bili), zinc (Zn), and magnesium (Mg) levels.</p> <p><strong>Results:</strong> Serum Bili levels significantly increased 1and 3 days after bone defect creation in both study and control groups, while the levels returned back to baseline in a study group, 7 days after the operation. Serum Alb, Zn, and Mg levels showed a significant decrease in study and control groups, 1 day and 3 days after the operation, while the levels of these parameters returned back to baseline, in a study group, 7 days after bone defect.</p> <p><strong>Conclusion:</strong> Supplementation of PPE can affect serum antioxidants and this was accompanied by the increase in the bone healing rate process.</p> 2021-10-23T00:00:00+00:00 Copyright (c) 2021 Evaluation The Anti-Inflammatory Effect of Prepared Aloe Vera Gel in Sulcular Full Thickness Flap Induced in Rats Model 2021-10-23T12:34:27+00:00 Amal Hanna Aziz <p><strong>Background: </strong>Aloe Vera contains many inorganic electrolytes like iron, potassium, chromium, copper, sodium, calcium, and zinc that are vital parts that induced the wound healing process as a result of the ability to prevent injury to the epithelium and promote healing of injured tissues. It improves healing by increasing the blood supply and oxygen to the area of injury tissue.</p> <p><strong>Objective:</strong> To evaluate the anti-inflammatory effect of Aloe Vera on wound healing in rats with full thickness flap and insertion of Aloe vera gel at the site of injury throughout analysis of the activity level of serum interleukin-1beta (IL-1β).</p> <p><strong>Patients and Methods:</strong> Fifty five male rats were randomly divided into three groups: A-Aloe vera gel (25 rats), subdivided into (5) subgroups as a test group, B- Chlorhexidine gel (25 rats) was also subdivided randomly into (5) subgroups as a test group. Each subgroup (5rats) was exposed to surgery and filled with (AV) and CHX gel in both. C-non-surgical control group (5 rats) to obtain&nbsp; baseline data. A sulcular full thickness flap incision was carried out between the two maxillary central incisors. Blood samples for immunological studies were collected by cardiac puncture, at times (3, 5, 7, 10, and14 days) for estimation of serum (IL-1β) levels using Indirect ELISA Technique in all groups.</p> <p><strong>Results:</strong> A highly significant decrease of serum IL-1β in rat group (A) within 3 and 5days post-surgery, then the concentration of this cytokine started to increase on 7,10and 14days post-surgery, which is statistically non significantly affect with the control group (C), where it reaches the level of the control level before surgery.</p> <p><strong>Conclusion:</strong> Aloe vera shows anti-inflammatory effects by decreasing&nbsp; the inflammation of periodontal tissue post-surgery&nbsp; which could accelerate healing based on a significant increase in the level of serum (IL-1β), reaching the control level before surgery at 14days, post-surgery that indicated&nbsp; positive results of this study.</p> 2021-10-23T00:00:00+00:00 Copyright (c) 2021 Efficacy of Chamomile Mouthwash on Clinical And Serum Inflammatory Parameters in Relation to Chlorhexidine in Chronic Gingivitis Patients 2021-10-23T12:29:54+00:00 Dilyar Ahmed Baban <p><strong>Background: </strong>Oral and systemic infections are closely linked to poor oral hygiene. Chlorhexidine mouthwash, in addition to tooth brushing has been commonly recommended. About the fact that there is a lot of studies on the effectiveness of chamomile as an herbal mouthwash, there isn't much evidence on its competitive effect with chlorhexidine.</p> <p><strong>Objective:</strong> To determine the clinical and inflammatory effects of chamomile as mouthwash (MTC) in the treatment of chronic gingivitis and compare its effect with 0.12% chlorhexidine (CHX).</p> <p><strong>Patients and Methods:</strong> A total of 45 subjects aged 18-45 years with chronic gingivitis underwent scaling and polishing with oral hygiene instruction; 15 patients received 1% of (MTC) as mouthwash, 15 patients received 0.12% of chlorhexidine mouthwash, and 15 patients received scaling and polishing only (SRP). Mouthwash was twice daily for 14 days. At the start of the study, clinical periodontal parameters (PI, GI, and BOP) and blood samples were taken and after four weeks of treatment to estimate the levels of C-reactive protein (CRP), alkaline phosphatase (ALP) and total protein (TP).</p> <p><strong>Results:</strong> After 4 weeks of periodontal treatment, there was a significant decrease in clinical periodontal parameters (P&lt;0.01) and inflammatory markers (P&lt;0.05) in the MTC and CHX and S&amp;P alone groups. From periodontal treatment, there was no significant difference between the MTC and CHX groups with clinical periodontal parameters and inflammatory markers (P&lt;0.05), although there was a significant difference between the MTC, CHX groups, and the S&amp;P alone group in terms of clinical periodontal parameters and inflammatory markers (P&lt;0.05).</p> <p><strong>Conclusion:</strong> Chamomile has been shown to be comparable to CHX in terms of reducing gingivitis by decreasing clinical periodontal parameters and inflammatory chemical markers values such as CRP, ALP, and TP.</p> 2021-10-23T00:00:00+00:00 Copyright (c) 2021