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The current study tries to estimate the prevalence of hydrometra in local goats and to evaluate ultrasonic diagnosis, treatment with Cloprostenol and fertility rate in goats. The study was carried out from March-2018 until April-2019. A total of 86 goats which presented to the clinic of Veterinary Medicine College, the University of Diyala, for routine ultrasonic diagnosis of pregnancy were examined. Ten local goats, diagnosed with hydrometra. All animals were received (250μg) Cloprostenol. Six of these goats were responses to the treatment with Cloprostenol from the first dose (n = 6, Group I), while other (n = 4, Group II) were responding after the second administration with a one-week interval. The results observed that the prevalence of hydrometra in local goats was (8.6%,10/86), and the responding rate for Group I and Group II were (60%,6/10) and (40%,4/10), respectively. While the pregnancy rate was (66.7%,4/6) and (50%,2/4) for Group I and Group II, respectively, with highly significant differences between these two groups at (P≤0.01). In conclusion, it can be concluded that real-time ultrasound approach is a reliable, rapid and useful tool for diagnosis and follow-up of goats affected with hydrometra. Successful treatment of goat with hydrometra and subsequent fertility was achieved using two doses of Cloprostenol one week apart.