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Recently, the concentration in nanoparticles of zinc oxide (Zn NP) has increased due to its wide application in veterinary science. Thus, Zn NP can be used in small doses in livestock feed to provide better results than traditional zinc sources and avoid indirect pollution to the environment. Twenty-five of the apparently healthy local Iraqi goats, aged 6 months and weighing 15.5 ± 1.05 kg, were used to conduct the present study. Experimental animals fed green fodder and barley straw. Also, it was fed on mixed feed mixture at 500 g / head / day. Create zinc deficiency by increasing the level of calcium and phosphorous in the diet. Animals were randomly divided into 5 groups, 5 in each group. The group (group 1) were left untreated, while those in group (group 2) were treated orally with 25 mg / kg of zinc oxide nanoparticles. Meanwhile, group (III) was treated orally at 75 mg / kg with zinc oxide nanoparticle, group (IV) was treated orally with 25 mg / kg of zinc oxide, group (V) was treated orally at 75 mg / Kg of zinc oxide once / weekly for 10 doses. Criteria for this study include zinc serum, total serum proteins, albumin and globulin, as well as comet screening and phagocytic index. The results showed that the level of serum zinc increased significantly in the ninth week compared to week zero, and increased significantly in the second and third groups compared to the first, fourth and fifth groups. The total protein decreased significantly, but increased significantly in the second and third groups compared to the first, fourth and fifth groups. Serum significantly increased in the placebo group in the ninth week compared to week zero. Globulin decreased significantly, and between groups showed a significant increase in groups 2 and 3 compared to groups I, IV and V. Comet assay analysis showed somewhat less DNA damage in the treatment groups compared to the control group. The results of the phagocytosis index showed a significant increase in the ninth week in the treatment and control groups compared to the zero week. As for the groups, the third group showed the highest value. It is concluded from the study that the nanoparticles of zinc oxide can play an important role in the health of animals.